Staff

Yasuo WatanabeProfessor / M.D., Ph.D.last update : 2024.03.30

Japanese

Profile

Name: Yasuo Watanabe
Affiliation: Pharmacology
Subjects: Pharmacology I
Pharmacology II
Practice of Pharmacology
Pharmaco-biological Sciences
Official title: Professor
Degree: M.D., Ph.D.

Academic background

1987: M.D. Mie University School of Medicine, Mie, Japan

1992: Ph.D. Nagoya University School of Medicine, Nagoya, Japan

Career history

1992-1994: Post-doctoral Fellow, Vollum Institute, Oregon Health and Sciences University, Portland, OR, USA.

1995-1997: Research Associate, Dept. of Pharmacology, Nagoya University, School of medicine, Nagoya, Japan

1997-2000: Assistant Professor, Dept. of Pharmacology, Nagoya University, School of medicine, Nagoya, Japan

2001-2006: Associate Professor, Dept. of Physiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

2006- Full Professor, Dept. of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo, Japan

Academic societies

Nitric Oxide Society, Japanese Society for Neurochemistry, NO Society of Japan, The Physiological Society of Japan, The Japanese Pharmacological Society, Japanese Biochemical Society, Japanese Pharmaceutical Society

Research fields

Molecular mechanism for oxidant- and NO-dependent regulation of calcium-signaling. Cellular mechanisms of stroke and subarachnoid hemorrhage; focus on NO, oxidants, and cytokines.

Books

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細胞工学 34 No.4　渡邊泰男，石井功，蕨栄治　RSSの生合成系とタンパク質機能制御　372-376　学研メディカル秀潤社　2015　978-4-7809-0165-8
みてわかる薬学　図解　薬理学　渡邊泰男　薬効の個人差と薬理作用に影響を与える因子　71-75　南山堂　2015　978-4-525-72061-2
疾病の回復を促進する薬　渡邊泰男　3、4、5、6章　45-103　NHK出版　2013　978-4-595-31419-3

Papers

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[Original Paper] 　Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.　Echizen H., Hanaoka K., Shimamoto K., Hibi R., Toma-Fukai S., Ohno H., Sasaki E., Komatsu T., Ueno T., Tsuchiya Y., Watanabe Y., Otsuka T., Saito H., Nagatoishi S., Tsumoto K., Kojima H., Okabe T., Shimizu T., Urano Y.　Sci Rep　13　16456　2023　[Related links]
[Original Paper] 　Cystathionine γ-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism　Shoma Araki, Tsuyoshi Takata, Katsuhiko Ono, Tomohiro Sawa, Shingo Kasamatsu, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Yasuo Watanabe, Yukihiro Tsuchiya　Int J Mol Sci 　24　9982　2023　[Related links]
[Original Paper] 　Angiogenesis in the Outer Membrane of Chronic Subdural Hematomas through Thrombin-Cleaved Osteopontin and the Integrin α9 and Integrin β1 Signaling Pathways　Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Satoru Honma, Chiharu Suzuki, Masahiro Aoyama, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi　Biomedicines　24　1440　2023　[Related links]
[Original Paper]　Regulation of nitric oxide/reactive oxygen species redox signaling by nNOS splicing variants　Shingo Kasamatsu , Hiroyasu Tsutsuki, Tomoaki Ida, Tomohiro Sawa, Yasuo Watanabe, Takaaki Akaike, Hideshi Ihara　Nitric Oxide .　120　44-52　2022　[Related links]
[Original Paper]　Sequential expression of neutrophil chemoattractants in cerebrospinal fluid after subarachnoid hemorrhage.　Koji Osuka, Yasuo Watanabe, Chiharu Suzuki, Kenichiro Iwami, Shigeru Miyachi　Journal of neuroimmunology　357　577610-577610　2021　[Related links]
[Original Paper]　Sequential Expression of Chemokines in Chronic Subdural Hematoma Fluids after Trepanation Surgery.　Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Takahiro Nakura, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi　Journal of neurotrauma　38　1979-1987　2021　[Related links]
[Review]　Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal　Tsuyoshi Takata, Shoma Araki, Yukihiro Tsuchiya, Yasuo Watanabe　Int J Mol Sci　21　8750　2020　[Related links]
[Original Paper]　PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates　Kamata S, Oyama T, Saito K, Honda A, Yamamoto Y, Suda K, Ishikawa R, Itoh T, Watanabe Y, Shibata T, Uchida K, Suematsu M, Ishii I.　iScience　23　101727　2020　[Related links]
[Review](Cover image: Related links)　Coordination between Calcium/Calmodulin-Dependent Protein Kinase II and Neuronal Nitric Oxide Synthase in Neurons　Shoma Araki, Koji Osuka, Tsuyoshi Takata,Yukihiro Tsuchiya, Yasuo Watanabe　Int J Mol Sci　21　7997-　2020　[Related links]
[Review]　Persulfide signaling in stress-initiated CaM kinase response.　Tsuyoshi Takata, Shoma Araki, Yukihiro Tsuchiya, Yasuo Watanabe　Antioxidants & redox signaling　33　1308-1319　2020　[Related links]
[Original Paper] 　Expression of high mobility group B1 and toll-like receptor-nuclear factor κB signaling pathway in chronic subdural hematomas　Koji Osuka , Yasuo Watanabe, Nobuteru Usuda, Kenichiro Iwami, Shigeru Miyachi, Masakazu Takayas　PloS one　15(6)　e0233643　2020　[Related links]
[Original Paper]　The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation　Takata T, Tsukuda A, Tsuchiya Y, Akaike T, Watanabe Y.　Nitric Oxide　86　68–75　2019　[Related links]
[Original Paper]　Reactive sulfur species impair Ca2+/calmodulin-dependent protein kinase II via polysulfidation　Araki S, Takata T, Tsuchiya Y, Watanabe Y.　Biochem. Biophys. Res. Commun.　508 　550-555　2019　[Related links]
[Original Paper]　Redox regulation of Ca2+/calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residue　Takata T, Kimura J, Ihara H, Hatano N, Tsuchiya Y, Watanabe Y.　Free Radic. Biol. Med. 　130　99-106 　2019　[Related links]
[Original Paper]　Expression of Autophagy Signaling Molecules in the Outer Membranes of Chronic Subdural Hematomas.　Osuka K, Watanabe Y, Usuda N, Aoyama M, Takeuchi M, Takayasu M.　J. Neurotrauma　36　403-407　2019　[Related links]
[Original Paper]　 Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons. 　Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H.　Biochem. Biophys. Res. Commun.　495 　2165-2170 　2018　[Related links]
[Original Paper]　Subarachnoid hemorrhage induces neuronal nitric oxide synthase phosphorylation at Ser1412 in the dentate gyrus of the rat brain.　Wada K, Osuka K, Watanabe Y, Usuda N, Fukasawa M, Araki Y, Okamoto S, Wakabayashi T.　Nitric Oxide　81　67-74　2018 　[Related links]
[Original Paper]　Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.　 Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.　Nat Commun.　8　1177　2017　[Related links]
[Original Paper]　Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas. 　Osuka K, Watanabe Y, Usuda N, Aoyama M, Iwami K, Takeuchi M, Watabe T, Takayasu M. 　J Neurotrauma. 　34　1996-2000. 　2017　[Related links]
[Original Paper]　1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides. 　Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y. 　Free Radic Biol Med. 　104　118-128.　2017　[Related links]
[Original Paper]　Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. 　Hanaoka K, Sasakura K, Suwanai Y, Toma-Fukai S, Shimamoto K, Takano Y, Shibuya N, Terai T, Komatsu T, Ueno T, Ogasawara Y, Tsuchiya Y, Watanabe Y, Kimura H, Wang C, Uchiyama M, Kojima H, Okabe T, Urano Y, Shimizu T, Nagano T. 　Sci Rep. 　7　40227.　2017　[Related links]
[Original Paper]　Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation. 　Ihara H, Kitamura A, Kasamatsu S, Ida T, Kakihana Y, Tsutsuki H, Sawa T, Watanabe Y, Akaike T. 　Biochem J. 　474　1149-1162.　2017　[Related links]
[Original Paper]　Activation of Nuclear Factor-kappa B in Endothelial Cells of Chronic Subdural Hematoma Outer Membranes. 　Osuka K, Watanabe Y, Usuda N, Aoyama M, Kawaguchi R, Takeuchi M, Takayasu M. 　Neurosurgery. 　80　571-578.　2017　[Related links]
[Original Paper]　Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue.　　　　Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y.　　　Biochem J.　474　2547-2562.　2017　[Related links]
[Original Paper]　Expression of Caspase Signaling Components in the Outer Membranes of Chronic Subdural Hematomas.　　Osuka K, Watanabe Y, Usuda N, Aoyama M, Iwami K, Takeuchi M, Watabe T, Takayasu M.　　J Neurotrauma.　34　3192-3197　2017　[Related links]
[Original paper]　Activation of STAT3 in endothelial cells of chronic subdural hematoma outer membranes　Osuka K, Watanabe Y, Usuda N, Aoyama M, Kawaguchi R, Watabe T, Takayasu M.　World Neurosurg.　91　376-382　2016　[Related links]
[Review]　Regulation of calsium signals via redox modification　Watanabe Y.　Folia Pharmacol. Jpn (Japanese)　147　285-289　2016　[Related links]
[Original paper]　Expressions of Mitogen-Activated Protein Kinases in Chronic Subdural Hematoma Outer membranes　Aoyama M, Osuka K, Usuda N, Watanabe Y, Kawaguchi R, Nakura T, Takayasu M.　J Neurotrauma.　15　1064-1070　2015　[Related links]
[Original paper]　Increased ICP promotes CaMKII-mediated phosphorylation of neuronal NOS at Ser847 in the hippocampus immediately after subarachnoid hemorrhage　Makino K, Osuka K, Watanabe Y, Usuda N, Hara M, Aoyama M, Takayasu M, Wakabayashi T.　Brain Res.　1616　19-25　2015　[Related links]
[Original paper]　Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides　Abiko Y, Ishii I, Kamata S, Tsuchiya Y, Watanabe Y, Ihara H, Akaike T, Kumagai Y.　Chem Res Toxicol.　28　1796-1802　2015　[Related links]
[Original paper]　Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons.　Kasamatsu S, Watanabe Y, Sawa T, Akaike T, Ihara H.　Biochem J.　459　251-263　2014　[Related links]
[Original paper]　Eotaxin-3 activates Smad through the TGF-β1 pathway in chronic subdural hematoma outer membranes.　Osuka K, Watanabe Y, Usuda N, Aoyama M, Takeuchi M, Takayasu M.　J Neurotrauma.　31　1451-1456　2014　[Related links]
[Original paper]　Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.　Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T.　Proc Natl Acad Sci U S A.　111　7606-7611　2014　[Related links]
[Original paper]　Expression of suppressor of cytokine signaling 3 in cerebrospinal fluid after subarachnoid hemorrhage　Osuka K, Watanabe Y, Aoyama M, Nakura T, Matsuo N, Takayasu M.　J Neuroinflammation.　11　142　2014　[Related links]
[Original paper]　Activation of JAK-STAT3 signaling pathway in chronic subdural hematoma outer membranes　Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Shima H, Takeuchi M, Yasuda M, Takayasu M.　Neurosci Lett.　534　166?170　2013　[Related links]
[Original paper]　90-kDa ribosomal S6 kinase 1 is inhibited by S-glutathionylation of its active-site cysteine residue during oxidative stress 　Takata T, Tsuchiya Y, Watanabe Y.　FEBS Lett.　587　1681-1686　2013　[Related links]
[Original paper]　Nitric oxide enhances increase in cytosolic Ca2+ and promotes nicotine-triggered MAPK pathway in PC12 cells.　Kajiwara A, Tsuchiya Y, Takata T, Nyunoya M, Nozaki N, Ihara H, Watanabe Y.　Nitric Oxide.　34　3?9　2013　[Related links]
[Original paper]　Phosphorylation of neuronal nitric oxide synthase at Ser1412 in the dentate gyrus of rat brain after transient forebrain ischemia.　Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Takayasu M.　Neurochem Int.　63　269-274　2013　[Related links]
[Original paper]　Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage.　Osuka K, Watanabe Y, Yasuda M, Takayasu M.　Neurosci Lett.　514　2?5　2012　[Related links]
[Original paper]　Nitric oxide prevents phosphorylation of neuronal nitric oxide synthase at Serine1412 by inhibiting the Akt/PKB and CaM-K II signaling pathways　Song T, Hatano N, Sugimoto K, Horii M, Yamaguchi F, Tokuda M, Miyamoto Y, Kambe T, Watanabe Y.　Int J Mol Med.　30　15-20　2012　[Related links]
[Original paper]　Real-time monitoring of liver damage during ischemia-reperfusion using a nitric oxide-selective sensor in rat liver　Nakagawa A, Yokoyama Y, Suzuki H, Shoji K, Watanabe Y, Imamura A, Kokuryo T, Nagino M.　Br J Surg.　99　1120-1128　2012　[Related links]
[Original paper]　Activation of Ras/MEK/ERK signaling in chronic subdural hematoma outer membranes　Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Aoyama M, Niwa A, Nakura T, Takayasu M.　Brain Res.　13　98-103　2012　[Related links]
[Original paper]　Calcium/calmodulin-dependent protein kinases as potential targets of nitric oxide　Takata T, Kimura J, Tsuchiya Y, Naito Y, Watanabe Y.　Nitric Oxide.　25　145-152　2011　[Related links]
[Original paper]　Activation of PI3 kinase / Akt signaling in chronic subdural hematoma outer membranes. 　Funai M, Osuka K, Usuda N, Atsuzawa K, Inukai T, Yasuda M, Watanabe Y, Takayasu M.　J Neurotrauma.　28　1127-1131　2011　[Related links]
[Original paper]　Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation　Butturini E, Cavalieri E, de Prati AC, Darra E, Rigo A, Shoji K, Murayama N, Yamazaki H, Watanabe Y, Suzuki H, Mariotto S.　PLoS One.　6　e20174　2011　[Related links]
[Original paper]　Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells　Miyamoto Y, Sakai R, Maeda C, Takata T, Ihara H, Tsuchiya Y, Watanabe Y.　Nitric Oxide.　25　344-349　2011　[Related links]
[Original paper]　Activation of STAT1 in neurons following spinal cord injury in mice　Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Yasuda M, Aoshima C, Wakabayashi T, Takayasu M.　Neurochem Res. 　36　2236-2243　2011　[Related links]
[Original paper]　Hypothermia enhances the colocalization of calmodulin kinase IIα with neuronal nitric oxide synthase in the hippocampus following cerebral ischemia　Hayashi S, Osuka K, Watanabe Y, Yasuda M, Takayasu M, Wakabayashi T.　Neurosci Lett. 　505　228-232　2011　[Related links]
[Original Paper]　Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage. 　Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Wakabayashi T, Takayasu M. 　Brain Res.　1332　12-19. 　2010　[Related links]
[Original paper]　Inactivation of Ca2+/Calmodulin-dependent Protein Kinase I by S-Glutathionylation of the Active-site Cysteine Residue.　Kambe T., Song T., Takata T., Hatano N., Miyamoto Y., Nozaki N., Naito Y., Tokumitsu H., Watanabe Y. 　FEBS Lett. 　584　2478-2484　2010　[Related links]
[Original Paper]　Modification of endothelial nitric oxide synthase through AMPK after experimental subarachnoid hemorrhage. 　Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Yoshida J, Takayasu M. 　J Neurotrauma. 　26 　1157-65. 　2009　[Related links]
[Original Paper]　Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II. 　Song T, Hatano N, Kambe T, Miyamoto Y, Ihara H, Yamamoto H, Sugimoto K, Kume K, Yamaguchi F, Tokuda M, Watanabe Y. 　Biochem J. 　412　223-31. 　2008　[Related links]
[Original Paper]　原著論文 Activation of endothelial nitric oxide synthase following spinal cord injury in mice. 　Osuka K, Watanabe Y, Takagi T, Usuda N, Atsuzawa K, Yoshida J, Takayasu M. 　Neurosci Lett. 　436　265-8. 　2008　[Related links]
[Original Paper]　p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase. 　Song T, Sugimoto K, Ihara H, Mizutani A, Hatano N, Kume K, Kambe T, Yamaguchi F, Tokuda M, Watanabe Y. 　Biochem J. 　401　391-8. 　2007　[Related links]
[Original Paper]　Nitric oxide production in the ventilatory muscles in response to acute resistive loading. 　Vassilakopoulos T, Govindaraju K, Parthenis D, Eidelman DH, Watanabe Y, Hussain SN. 　Am J Physiol Lung Cell Mol Physiol. 　292　L1013-22. 　2007　[Related links]
[Original Paper]　Phosphorylation of neuronal nitric oxide synthase at Ser847 in the nucleus intermediolateralis after spinal cord injury in mice. 　Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Aoshima C, Yamauchi K, Takayasu M, Yoshida J. 　Neuroscience. 　24　 1-7 　2007　[Related links]
[Original Paper]　Phosphoinositide metabolism during membrane ruffling and macropinosome formation in EGF-stimulated A431 cells. 　Araki N, Egami Y, Watanabe Y, Hatae T. 　Exp Cell Res. 　313　1496-507 　2007　[Related links]
[Original Paper]　Phosphorylation of neuronal and endothelial nitric oxide synthase in the kidney with high and low salt diets. 　Mount PF, Fraser SA, Watanabe Y, Lane N, Katsis F, Chen ZP, Kemp BE, Power DA. 　Nephron Physiol. 　102　p36-50. 　2006　[Related links]
[Original Paper]　Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage. 　Osuka K, Watanabe Y, Yamauchi K, Nakazawa A, Usuda N, Tokuda M, Yoshida J. 　Brain Res. 　1072　1-7. 　2006　[Related links]
[Original Paper]　Clinical significance of Skp2 expression, alone and combined with Jab1 and p27 in epithelial ovarian tumors. 　Sui L, Dong Y, Watanabe Y, Yamaguchi F, Sugimoto K, Tokuda M. 　Oncol Rep. 　15　765-71. 　2006　[Related links]
[Original Paper]　Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors.　Sui L, Dong Y, Watanabe Y, Yamaguchi F, Sugimoto K, Tokuda M.　Oncol Rep. 　15　773-8. 　2006　[Related links]
[Original Paper]　Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. 　Nishi A, Watanabe Y, Higashi H, Tanaka M, Nairn AC, Greengard P. 　Proc Natl Acad Sci U S A. 　102　1199-204. 　2005　[Related links]
[Original Paper]　Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas. 　Dong Y, Sui L, Watanabe Y, Yamaguchi F, Hatano N, Tokuda M. 　Clin Cancer Res. 　11　259-66. 　2005　[Related links]
[Original Paper]　Growth inhibitory effect of D-allose on human ovarian carcinoma cells in vitro. 　Sui L, Dong Y, Watanabe Y, Yamaguchi F, Hatano N, Izumori K, Tokuda M. 　Anticancer Res. 　25　2639-44. 　2005　[Related links]
[Original Paper]　The inhibitory effect and possible mechanisms of D-allose on cancer cell proliferation.　 Sui L, Dong Y, Watanabe Y, Yamaguchi F, Hatano N, Tsukamoto I, Izumori K, Tokuda M.　 Int J Oncol. 　27　907-12. 　2005　[Related links]
[Original Paper]　Inhibition of neuronal nitric-oxide synthase by phosphorylation at Threonine1296 in NG108-15 neuronal cells. 　Song T, Hatano N, Kume K, Sugimoto K, Yamaguchi F, Tokuda M, Watanabe Y.　FEBS Lett. 　579 　5658-62. 　2005　[Related links]
[Original Paper]　Neuroprotective effect of D-psicose on 6-hydroxydopamine-induced apoptosis in rat pheochromocytoma (PC12) cells. 　Takata MK, Yamaguchi F, Nakanose K, Watanabe Y, Hatano N, Tsukamoto I, Nagata M, Izumori K, Tokuda M. 　J Biosci Bioeng. 　100 　511-6. 　2005　[Related links]
[Original Paper]　Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei. 　Agostino PV, Ferreyra GA, Murad AD, Watanabe Y, Golombek DA. 　Neurochem Int. 　44　617-25. 　2004　[Related links]
[Original Paper]　Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells. 　Takenouchi Y, Oo ML, Senga T, Watanabe Y, Machida K, Miyazaki K, Nimura Y, Hamaguchi M. 　Oncol Rep. 　11　1059-62. 　2004　[Related links]
[Original Paper]　Phosphohippolin expression in the rat central nervous system. 　Kadowaki K, Sugimoto K, Yamaguchi F, Song T, Watanabe Y, Singh K, Tokuda M. 　Brain Res Mol Brain Res. 　125　105-12. 　2004　[Related links]
[Original Paper]　Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation. 　Song T, Hatano N, Horii M, Tokumitsu H, Yamaguchi F, Tokuda M, Watanabe Y. 　FEBS Lett. 　570　133-7. 　2004　[Related links]
[Original Paper]　Modification of endothelial NO synthase through protein phosphorylation after forebrain cerebral ischemia/reperfusion. 　Osuka K, Watanabe Y, Usuda N, Nakazawa A, Tokuda M, Yoshida J. 　Stroke　35　2582-6. 　2004　[Related links]
[Original Paper]　S-phase kinase-associated protein 2 expression in laryngeal squamous cell carcinomas and its prognostic implications.　 Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. 　Oncol Rep. 　10 　321-5. 　2003　[Related links]
[Original Paper]　Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. 　Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, Tezuka T, Yamamoto T, Tokuda M. 　Biochem J. 　372(Pt 2) 　465-471.　2003　
[Original Paper]　Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptors. 　Mamiya T, Yamada K, Miyamoto Y, K?nig N, Watanabe Y, Noda Y, Nabeshima T. 　Mol Psychiatry. 　8 　752-65. 　2003　[Related links]
[Original Paper]　A novel inhibitory effect of D-allose on production of reactive oxygen species from neutrophils. 　 Murata A, Sekiya K, Watanabe Y, Yamaguchi F, Hatano N, Izumori K, Tokuda M. 　J Biosci Bioeng 　96　89-91. 　2003　[Related links]
[Original Paper]　Clinical relevance of cyclin B1 overexpression in laryngeal squamous cell carcinoma. 　Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M.　Cancer Lett. 　177　13-9. 　2002　[Related links]
[Original Paper]　Aberrant expression of cyclin A in laryngeal squamous cell carcinoma. 　Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. 　Anticancer Res. 　22(1A) 　83-9. 　2002　[Related links]
[Original Paper]　Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. 　Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tokuda M.　 Int J Oncol. 　21　315-20. 　2002　[Related links]
[Original Paper]　Survivin expression in laryngeal squamous cell carcinomas and its prognostic implications. 　Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M. 　Anticancer Res. 　22　2377-83. 　2002　[Related links]
[Original Paper]　Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia. 　Osuka K, Watanabe Y, Usuda N, Nakazawa A, Fukunaga K, Miyamoto E, Takayasu M, Tokuda M, Yoshida J. 　J Cereb Blood Flow Metab. 　22　1098-106. 　2002　[Related links]
[Original Paper]　Expression of p57kip2 and its clinical relevance in epithelial ovarian tumors.　Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K, Tokuda M. 　Anticancer Res. 　22(6A) 　3191-6. 　2002　[Related links]
[Original Paper]　Dephosphorylation of nNOS at Ser(847) by protein phosphatase 2A.　Komeima K, Watanabe Y. 　FEBS Lett. 　497　65-6. 　2001　[Related links]
[Original Paper]　Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. 　Komeima K, Hayashi Y, Naito Y, Watanabe Y. 　J Biol Chem. 　275　28139-43. 　2000　[Related links]
[Original Paper]　Regulation of neuronal nitric-oxide synthase by calmodulin kinases.　Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, Watanabe Y.　J Biol Chem.　274　20597-20602.　1999　[Related links]
[Original Paper]　Multi-modality assessment of nitric oxide synthase inhibition in focal cerebral ischemia Koketsu N., Suzuki Y., Watanabe Y., Takayasu M., Kano T., Dogan A., Shibuya M., Saito K., and Yoshida J. 　Koketsu N., Suzuki Y., Watanabe Y., Takayasu M., Kano T., Dogan A., Shibuya M., Saito K., and Yoshida J. 　J. Neurovascular Disease 　3 　243-252 　1998　
[Original Paper]　Cloning and expression of a cDNA encoding a new neurocalcin isoform (neurocalcin alpha) from bovine brain. 　Kato M, Watanabe Y, Iino S, Takaoka Y, Kobayashi S, Haga T, Hidaka H. 　Biochem J. 　331 ( Pt 3) 　871-6. 　1998　[Related links]
[Original Paper]　Inducible cyclooxygenase expression in canine basilar artery after experimental subarachnoid hemorrhage. Osuka K, Suzuki Y, Watanabe Y, Takayasu M, Yoshida J. Stroke. 29 1219-22. 1998　Osuka K, Suzuki Y, Watanabe Y, Takayasu M, Yoshida J. 　Stroke. 　29 　1219-22. 　1998　[Related links]
[Original Paper]　Inter-isoformal regulation of nitric oxide synthase through heteromeric dimerization. 　Watanabe Y, Nishio M, Hamaji S, Hidaka H. 　Biochim Biophys Acta. 　1388　199-208. 　1998　[Related links]
[Original Paper]　HMN-1180, a small molecule inhibitor of neuronal nitric oxide synthase. 　Nishio M, Watanabe Y, Hidaka H. 　J Pharmacol Exp Ther. 　287　1063-7. 　1998　[Related links]
[Original Paper]　Neuronal nitric oxide synthase-membrane phospholipid interactions. 　Watanabe Y, Nishio M, Hamaji S, Hayashi Y, Hu Y, Hidaka H. 　Arch Biochem Biophys. 　358　68-73. 　1998 　[Related links]
[Original Paper]　Identification of a specific amino acid cluster in the calmodulin-binding domain of the neuronal nitric oxide synthase. 　Watanabe Y, Hu Y, Hidaka H.　FEBS Lett. 　403　75-8. 　1997　
[Original Paper]　Vasodilator effects on canine basilar artery induced by intracisternal interleukin-1 beta. 　Osuka K, Suzuki Y, Watanabe Y, Dogan A, Takayasu M, Shibuya M, Yoshida J.　J Cereb Blood Flow Metab. 　17 　1337-45. 　1997　[Related links]
[Original Paper]　Isoform-specific activation and structural diversity of calmodulin kinase I. 　Naito Y, Watanabe Y, Yokokura H, Sugita R, Nishio M, Hidaka H.　 J Biol Chem. 　272　32704-8. 　1997　
[Original Paper]　Activation of calcineurin A subunit phosphatase activity by its calcium-binding B subunit. 　Watanabe Y, Perrino BA, Soderling TR. 　Biochemistry. 　35　562-6. 　1996　[Related links]
[Original Paper]　Neuronal nitric oxide synthase specific autophosphorylation in baculovirus/Sf9 insect cell system. 　Watanabe Y, Terashima K, Hidaka H. 　Biochem Biophys Res Commun. 　219　638-43. 　1996　[Related links]
[Original Paper]　A new and potent calmodulin antagonist, HF-2035, which inhibits vascular relaxation induced by nitric oxide synthase. 　Win NH, Ishikawa T, Saito N, Kato M, Yokokura H, Watanabe Y, Iida Y, Hidaka H.　Eur J Pharmacol. 　299　119-26. 　1996　[Related links]
[Original Paper]　Isoform-specific intracellular vesicle formation by recombinant annexin XI-A in Sf9 cells. 　Sudo T, Mamiya N, Goto M, Watanabe Y, Hidaka H. 　Biochem Biophys Res Commun. 　223　706-11. 　1996　[Related links]
[Original Paper] 　Identification in the calcineurin A subunit of the domain that binds the regulatory B subunit.　Watanabe Y, Perrino BA, Chang BH, Soderling TR. 　J Biol Chem. 　270　456-60.　1995　[Related links]
[Original Paper]　Calvasculin, as a factor affecting the microfilament assemblies in rat fibroblasts transfected by src gene. 　Watanabe Y, Usada N, Minami H, Morita T, Tsugane S, Ishikawa R, Kohama K, Tomida Y, Hidaka H. 　FEBS Lett. 　324　51-5. 　1993　[Related links]
[Original Paper]　Relaxant effects of various xanthine derivatives. Relationship to cyclic nucleotide phosphodiesterase inhibition. 　Takagi K, Ogawa K, Tanaka H, Satake T, Watanabe Y, Chijiwa T, Hidaka H. 　Adv Second Messenger Phosphoprotein Res 　25　353-62. 　1992　[Related links]
[Original Paper]　Isolation and characterization of a calcium-binding protein derived from mRNA termed p9Ka, pEL-98, 18A2, or 42A by the newly synthesized vasorelaxant W-66 affinity chromatography. 　Watanabe Y, Kobayashi R, Ishikawa T, Hidaka H. 　Arch Biochem Biophys. 　292　563-9. 　1992　[Related links]
[Original Paper]　Calvasculin, an encoded protein from mRNA termed pEL-98, 18A2, 42A, or p9Ka, is secreted by smooth muscle cells in culture and exhibits Ca(2+)-dependent binding to 36-kDa microfibril-associated glycoprotein. 　Watanabe Y, Usuda N, Tsugane S, Kobayashi R, Hidaka H.　 J Biol Chem. 　267 　17136-40. 　1992　[Related links]
[Original Paper]　Specific binding of CAP-50 to calcyclin. 　Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H. 　FEBS Lett. 　305　217-9. 　1992 　[Related links]
[Review]　[Trend in the development of new inhibitors of cyclic nucleotide metabolism and their clinical application]. 　Hidaka H, Hagiwara M, Watanabe Y. 　Nihon Rinsho. 　49　961-7. 　1991　[Related links]

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[Special lecture/Symposium] 　Regulation of neuronal nitric oxide synthase by supersulfides　?Yukihiro Tsuchiya, Shoma Araki, Yasuo Watanabe　Redox Week in Sendai 2022　仙台　2022/10/30
[Special