薬品物理化学研究室

昭和薬科大学研究室一覧

昭和薬科大学研究室一覧

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Hiromichi AkizawaProfessor / Ph.D.last update : 2022.12.17

Japanese

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Name
Hiromichi Akizawa
Affiliation
Laboratory of Physical Chemistry
Subjects
　
Official title
Professor
Degree
Ph.D.

Books

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  • マクマリー 生物有機化学 基礎化学編 第４版（原書第７版）　秋澤宏行（訳）　第11章　核化学　352-382　丸善出版　2015　978-4-621-08895-1
  • コンパス 物理化学 改訂第2版　秋澤宏行　13章　放射線と放射能　223-238　南江堂　2014　978-4-524-40315-8
  • NEW 放射化学?放射薬品学 (第2版)　秋澤宏行、村上美穂　第4章　放射線測定法（第5-8節）　66-76　廣川書店　2011　978-4-567-26151-7
  • 無機化合物?錯体 －生物無機化学の基礎－ (第2版)　秋澤宏行　第2章　放射性同位体 (放射性核種)　25-35　廣川書店　2010　978-4-567-21151-2
  • Technetium-99m Radiopharmaceuticals: Status and Trends.　H. Akizawa, T. Uehara, Y. Arano.　Chapter 12. Technetium-99m radiopharmaceuticals for monitoring drug resistance　255-267　Publishing Section, International Atomic Energy Agency　2009　978-92-0-103509-7
  • Technetium-99m Radiopharmaceuticals: Status and Trends.　T. Uehara, H. Akizawa, Y. Arano.　Chapter 13. Technetium-99m radiopharmaceuticals for lymphoscintigraphy　269-280　Publishing Section, International Atomic Energy Agency　2009　978-92-0-103509-7

Papers

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  • [Original paper]　Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS.　M. Shukuri, M. Uchino, T. Sakamaki, S. Onoe, R. Hosoi, K. Todoroki, Y. Arano, T. Sakai, H. Akizawa, O. Inoue.　Biochem. Biophys. Res. Commun.　584　101-106　2021　
  • [Original paper]　Influence of linker molecules in hexavalent RGD peptides on their multivalent interactions with integrin αvβ3.　Y. Mizuno, K. Kimura, S. Onoe, M. Shukuri, Y. Kuge, H. Akizawa.　J. Med. Chem.　64(21)　16008-16019　2021　
  • [Original paper]　Aryl isocyanide derivative for one-pot synthesis of purification-free 99mTc-labeled hexavalent targeting probe.　Y. Mizuno, T. Uehara, C. Jen, H. Akizawa, Y. Arano.　Nucl. Med. Biol.　86-87　30-36　2020　
  • [Original paper]　The synthesis of a 99mTc-labeled tetravalent targeting probe upon isonitrile coordination to 99mTcI for enhanced target uptake in saturable systems.　Y. Mizuno, T. Uehara, C. Jen, H. Akizawa, Y. Arano.　RSC Adv.　9　26126-26135　2019　
  • [Original paper]　Coordination-mediated synthesis of purification-free bivalent 99mTc-labeled probes for in vivo imaging of saturable system.　Y. Taira, T. Uehara, M. Tsuchiya, H. Takemori, Y. Mizuno, S. Takahashi, H. Suzuki, H. Hanaoka, H. Akizawa, Y. Arano.　Bioconjugate Chem.　29(2)　459-466　2018　
  • [Original paper]　111In-DTPA-D-Phe-1-Asp0-D-Phe1-octreotide exhibits higher tumor accumulation and lower renal radioactivity than 111In-DTPA-D-Phe1-octreotide.　N. Oshima, H. Akizawa, H. Kitaura, H. Kawashima, S. Zhao, Y. Zhao, K. Nishijima, Y. Kitamura, Y. Arano, Y. Kuge, K. Ohkura.　Nucl. Med. Biol.　54　18-26　2017　
  • [Original paper]　Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity.　N. Oshima, H. Akizawa, H. Kawashima, S. Zhao, Y. Zhao, K. Nishijima, Y. Kitamura, Y. Arano, Y. Kuge, K. Ohkura.　Nucl. Med. Biol.　48　16-25　2017　
  • [Original paper]　The Thymidine Phosphorylase Imaging Agent 123I-IIMU Predicts the Efficacy of Capecitabine.　N. Kobashi, H. Matsumoto, S. Zhao, S. Meike, Y. Okumura, T. Abe, H. Akizawa, K. Ohkura, K. Nishijima, N. Tamaki, Y. Kuge.　J. Nucl. Med.　57(8)　1276-1281　2016　
  • [Original paper]　Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice.　Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y.　Ann. Nucl. Med.　29(7)　582-587　2015　
  • [Original paper]　Design, synthesis and biological evaluation of negatively charged 111In-DTPA-octreotide derivatives.　N. Oshima, H. Akizawa, S. Zhao, Y. Zhao, K. Nishijima, Y. Kitamura, Y. Arano, Y. Kuge, K. Ohkura　Bioorg. Med. Chem.　22(4)　1377-1382　2014　
  • [Original paper]　Renal brush border enzyme-cleavable linkages for low renal radioactivity levels of radiolabeled antibody fragments.　H. Akizawa, M. Imajima, H. Hanaoka, T. Uehara, S. Satake, Y. Arano.　Bioconjugate Chem.　24(2)　291-299　2013　
  • [Original paper]　Chemical Design of 99mTc-Labeled Probes for Targeting Osteogenic Bone Region.　M. Yanagi, T. Uehara, Y. Uchida, S. Kiyota, M. Kinoshita, Y. Higaki, H. Akizawa, H. Hanaoka, Y. Arano.　Bioconjugate Chem.　24(7)　1248-1255　2013　
  • [Original paper]　Versatile photorearrangement of photocycloadducts from 5-fluoro-1,3-dimethyluracil and naphthalene.　K. Ohkura, H. Akizawa, M. Kudo, T. Ishihara, N. Oshima, K. Seki.　Heterocycles　84(2)　1057-1065　2012　
  • [Original paper]　Synthesis and evaluation of diastereoisomers of 1,4,7-triazacyclononane-1,4,7-tris-(glutaric acid) (NOTGA) for multimeric radiopharmaceuticals of gallium.　F. L. Guerra Gomez, T. Uehara, T. Rokugawa, Y. Higaki, H. Suzuki, H. Hanaoka, H. Akizawa, Y. Arano.　Bioconjugate Chem.　23(11)　2229-2238　2012　
  • [Original paper]　Radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase: Suppressed accumulation into tumor cells by target gene knockdown.　H. Li, S. Zhao, Y. Jin, K. Nishijima, H. Akizawa, K. Ohkura, N. Tamaki, Y. Kuge.　Nucl. Med. Commun.　32(12)　1211-1215　2011　
  • [Original paper]　Toward in vivo imaging of heart disease using a radiolabeled single-chain Fv fragment targeting tenascin-C.　N. Kobayashi, K. Odaka, T. Uehara, K. Imanaka-Yoshida, Y. Kato, H. Oyama, H. Tadokoro, H. Akizawa, S. Tanada, M. Hiroe, T. Fukumura, I. Komuro, Y. Arano, T. Yoshida, T. Irie.　Anal. Chem.　83(23)　9123-9130　2011　

Conference, etc.

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  • [Oral presentation]　Development of 99m Tc-labeled hexavalent c(RGDfK) peptide with optimized linker structure for in vivo imaging of integrin αvβ3　Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri, Yuji Kuge, Hiromichi Akizawa　The Fourth International Symposium on Technetium and Other Radiometals in Chemistry and Medicine　Bressanone, Italy　2022/09/14～2022/09/17
  • [Poster presentation]　Improvement of fatty acid binding protein-4 imaging probe having triazolopyrimidinone structure　Arisa Taguchi, Naoya Kondo, Tamami Sonoda, Satoru Onoe, Hiromichi Akizawa, Takashi Temma　The 142nd Annual Meeting the Pharmaceutical Society of Japan　Nagoya, Japan　2022/03/25～2022/03/28
  • [Poster presentation]　The study on transporters involved in uptake of thymidine phosphorylase imaging agent 123I-IIMU by using transporter transiently expressing cell lines　Mai Hasegawa, Miho Shukuri, Satoru Onoe, Yuki Mizuno, Yuji Kuge, Hiromichi Akizawa　The 142nd Annual Meeting the Pharmaceutical Society of Japan　Nagoya, Japan　2022/03/25～2022/03/28
  • [Oral presentation]　2価環状RGDペプチドのスペーサ構造がintegrin αvβ3陽性細胞との相互作用に与える影響　水野雄貴、宮本莉里、尾江悟、宿里充穗、久下裕司、秋澤宏行　第4回日本核医学会分科会 放射性薬品科学研究会 第20回放射性医薬品?画像診断薬研究会　Sendai, Japan　2021/09/25
  • [Poster presentation]　Fatty acid binding protein-4標的PETプローブの開発に向けた新規フッ化アリール結合triazolopyrimidine誘導体の合成　尾江悟?田中裕之?佐藤隆浩?水野雄貴?宿里充穗?近藤直哉?天滿敬?秋澤宏行　第65回日本薬学会関東支部大会　Chiba, Japan　2021/09/11
  • [Oral presentation]　Influence of linker structure of multivalent RGD peptides on the interaction with integrin αvβ3 positive tumors　Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri, Yuji Kuge, Hiromichi Akizawa　The 141st Annual Meeting the Pharmaceutical Society of Japan　Hiroshima, Japan　2021/03/26～2021/03/29
  • [Poster presentation]　Development of Glyoxalase I-targeted SPECT probes: investigation of diester form of radioiodinated glutathione analogues　Kanon Takado, Satoru Onoe, Keisuke Sasano, Ayami Hirano, Miho Nagasaki, Yuki Mizuno, Miho Shukuri, Hiromichi Akizawa　The 141st Annual Meeting the Pharmaceutical Society of Japan　Hiroshima, Japan　2021/03/26～2021/03/29
  • [Oral presentation]　Biodistribution of 111In-DTPA-L-Phe?1-Asp0-D-Phe1-octreotide in tumor-bearing nude mice　Nobuhiro Oshima, Hiroki Shikanai, Yuji Kameyama, Hirotake Kitaura, Hiromichi Akizawa　The 140th Annual Meeting the Pharmaceutical Society of Japan　Kyoto, Japan　2020/03/25～2020/03/28
  • [Poster presentation]　In vitro and in vivo evaluation of 111In-1B4M-DTPA (tiuxetan)-conjugated octreotide derivatives for application to theranostics　Shiho Nakaue, Nobuhiro Oshima, Hiroki Shikanai, Masashi Shiba, Ryo Nakagawara, Kanta Yamamoto, Ryo Saito, Hirotake Kitaura, Hiromichi Akizawa　The 140th Annual Meeting the Pharmaceutical Society of Japan　Kyoto, Japan　2020/03/25～2020/03/28
  • [Poster presentation]　Structure-cellular uptake relationship of 111In-DTPA-AA?1-Asp0-D-Phe1-octreotide derivatives　Ryo Nakagawara, Nobuhiro Oshima, Shiho Nakaue, Yuu Ohmi, Fumihiro Kondo, Hirotake Kitaura, Hiromichi Akizawa　The 140th Annual Meeting the Pharmaceutical Society of Japan　Kyoto, Japan　2020/03/25～2020/03/28
  • [Oral presentation]　The syntheses of Technetium(I)-99m complexes with chelating bidentate isonitrile ligands for molecular imaging 　Haruka Amemiya, Yuki Mizuno, Satoru Onoe, Miho Shukuri, Yasushi Arano, Hiromichi Akizawa　The 29th Symposium on Roles of Metals in Biological Reactions, Biology and Medicine　Osaka, Japan　2019/05/31～2019/06/01
  • [Poster presentation]　Synthesis and preliminary evaluation of radioiodinated cyanine dyes for SPECT/fluorescence dual imaging of tumor　Shogo Kikuchi, Satoru Onoe, Sarina Nishi, Yuki Mizuno, Miho Shukuri, Hideo Saji, Hiromichi Akizawa 　The 139th Annual Meeting the Pharmaceutical Society of Japan　Chiba, Japan　2019/03/20～2019/03/23
  • [Poster presentation]　The effect of linker length of multivalent RGD peptides on the uptake and retention in integrin αvβ3 positive cells　Kohta Kimura, Yuki Mizuno, Riri Miyamoto, Hiromichi Akizawa　The 139th Annual Meeting the Pharmaceutical Society of Japan　Chiba, Japan　2019/03/20～2019/03/23
  • [Oral presentation]　Synthesis and evaluation of a 99mTc-labeled hexavalent targeting probe from a monovalent ligand for in vivo imaging of saturable systems　Yuki Mizuno, Nagiho Komatsu, Tomoya Hehara, Hiromichi Akizawa, Yasushi Arano　The 3rd International Symposium on Technetium and Other Radiometals in Chemistry and Medicine The 3rd International Symposium on Technetium and Other Radiometals in Chemistry and Medicine　Bressanone, Italy　2018/09/26～2018/09/29
  • [Poster presentation]　Preparation of hexacoordinated 99mTcI complexes using bidentate isonitrile ligands: Effect of linker structure on the radiolabeling yields　Haruka Amemiya, Yuki Mizuno, Yasushi Arano, Hiromichi Akizawa　The 138th Annual Meeting the Pharmaceutical Society of Japan　Kanazawa, Japan　2018/03/25～2018/03/28
  • [Poster presentation]　Effect of organic cation transporters on tumor uptake of the thymidine phosphorylase imaging agent [125I]-IIMU　Kenji Nakayama, Miho Shukuri, Kei Higashikawa, Satoru Onoe, Yuki Mizuno, Kazue Ohkura, Yuji Kuge, Hiromichi Akizawa　The 138th Annual Meeting the Pharmaceutical Society of Japan　Kanazawa, Japan　2018/03/25～2018/03/28
  • [Poster presentation]　111In-DTPA-L-Phe－1-Asp0-D-Phe1-octreotide の正常マウスでの体内動態および in vitro腫瘍集積性の評価　Nobuhiro Oshima, Yuji Kameyama, Hiroki Shikanai, Hirotake Kitaura, Hiromichi Akizawa, Kazue Ohkura　The 138th Annual Meeting the Pharmaceutical Society of Japan　Kanazawa, Japan　2018/03/25～2018/03/28
  • [Poster presentation]　がん集積性シアニン系色素の放射性標識誘導体化に関する基礎的検討　紺野龍平、尾江悟、菊地正悟、布施有理、窪田奈々、秋澤宏行　第61回日本薬学会関東支部大会　東京　2017/09/16
  • [Poster presentation]　Elucidation of control factors for photo-induced reactions between uracil derivatives and aromatics　Kazue Ohkura, Nobuhiro Oshima, Hirotake Kitaura, Hiromichi Akizawa, Koh-ichi Seki　The 97th CSJ Annual Meeting　Yokohama, Japan　2017/03/16～2017/03/19
  • [Poster presentation]　放射性ヨウ素を導入したGlyoxalase I阻害剤の合成　平野愛耶美、尾江悟、鈴木友